Histone H3 Lysine4 Acetylation-Methylation Dynamics Define Breast Cancer Subtypes
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Joe Boyd
PROVIDER: E-GEOD-75169 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Histone H3 lysine 4 acetylation and methylation dynamics define breast cancer subtypes.
Messier Terri L TL Gordon Jonathan A R JA Boyd Joseph R JR Tye Coralee E CE Browne Gillian G Stein Janet L JL Lian Jane B JB Stein Gary S GS
Oncotarget 20160201 5
The onset and progression of breast cancer are linked to genetic and epigenetic changes that alter the normal programming of cells. Epigenetic modifications of DNA and histones contribute to chromatin structure that result in the activation or repression of gene expression. Several epigenetic pathways have been shown to be highly deregulated in cancer cells. Targeting specific histone modifications represents a viable strategy to prevent oncogenic transformation, tumor growth or metastasis. Meth ...[more]
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