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Mouse bone marrow Mesenchymal Stem Cells (MSC) exposed to activated T cells

ABSTRACT: To analyze the changes induced in MSC transcriptome by activated T cells, MSC were co-cultured in transwell with anti CD3/CD28 activated T cells for 48 hrs before RNA extraction IFNÎ³-induced plasticity of mesenchymal stem cells is regulated by STATs through inhibition of mTOR and TGFÎ² pathways. Vigo T, Procaccini C, Ferrara G, Baranzini S, Oksenberg J, Diaspro A, Kerlero de Rosbo N, Uccella A. The expression of MSC co-cultured with activated T cells ( two replicates) were compared to that of naive MSC (3 replicates)

ORGANISM(S): Mus musculus

SUBMITTER: Tiziana Vigo

PROVIDER: E-GEOD-75749 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Mouse bone marrow Mesenchymal Stem Cells (MSC) exposed to activated T cells

Project description:To analyze the changes induced in MSC transcriptome by activated T cells, MSC were co-cultured in transwell with anti CD3/CD28 activated T cells for 48 hrs before RNA extraction IFNγ-induced plasticity of mesenchymal stem cells is regulated by STATs through inhibition of mTOR and TGFβ pathways. Vigo T, Procaccini C, Ferrara G, Baranzini S, Oksenberg J, Diaspro A, Kerlero de Rosbo N, Uccella A.

2015-12-08 | GSE75749 | GEO

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