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Transcription profiling of Drosophila fly heads treated with CHX, dexamethasone vs. controls

ABSTRACT: CLK targets from fly heads using the TIM-GAL4; UAS-CLKGR line Experiment Overall Design: Fly heads were stimulated with vehicle + CHX or dexamethasone + CHX

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Sebastian Kadener

PROVIDER: E-GEOD-7646 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Clockwork Orange is a transcriptional repressor and a new Drosophila circadian pacemaker component.

Kadener Sebastian S Stoleru Dan D McDonald Michael M Nawathean Pipat P Rosbash Michael M

Genes & development 20070619 13

Many organisms use circadian clocks to keep temporal order and anticipate daily environmental changes. In Drosophila, the master clock gene Clock promotes the transcription of several key target genes. Two of these gene products, PER and TIM, repress CLK-CYC-mediated transcription. To recognize additional direct CLK target genes, we designed a genome-wide approach and identified clockwork orange (cwo) as a new core clock component. cwo encodes a transcriptional repressor that synergizes with PER ...[more]

PMID: 17578907

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