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Transcription profiling of Drosophila heads from 5073 strain at multiple time points

ABSTRACT: 6 Timepoints from 5073 strain Experiment Overall Design: Fly head microarray from 6 Timepoints using 5073 strain

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Sebastian Kadener

PROVIDER: E-GEOD-7651 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Clockwork Orange is a transcriptional repressor and a new Drosophila circadian pacemaker component.

Kadener Sebastian S Stoleru Dan D McDonald Michael M Nawathean Pipat P Rosbash Michael M

Genes & development 20070619 13

Many organisms use circadian clocks to keep temporal order and anticipate daily environmental changes. In Drosophila, the master clock gene Clock promotes the transcription of several key target genes. Two of these gene products, PER and TIM, repress CLK-CYC-mediated transcription. To recognize additional direct CLK target genes, we designed a genome-wide approach and identified clockwork orange (cwo) as a new core clock component. cwo encodes a transcriptional repressor that synergizes with PER ...[more]

PMID: 17578907

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