Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Aravind Tallam
PROVIDER: E-GEOD-76563 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Tallam Aravind A Perumal Thaneer M TM Antony Paul M PM Jäger Christian C Fritz Joëlle V JV Vallar Laurent L Balling Rudi R Del Sol Antonio A Michelucci Alessandro A
PloS one 20160212 2
Immunoresponsive gene 1 (IRG1) is one of the highest induced genes in macrophages under pro-inflammatory conditions. Its function has been recently described: it codes for immune-responsive gene 1 protein/cis-aconitic acid decarboxylase (IRG1/CAD), an enzyme catalysing the production of itaconic acid from cis-aconitic acid, a tricarboxylic acid (TCA) cycle intermediate. Itaconic acid possesses specific antimicrobial properties inhibiting isocitrate lyase, the first enzyme of the glyoxylate shunt ...[more]