Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Aravind Tallam
PROVIDER: E-GEOD-76561 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
PloS one 20160212 2
Immunoresponsive gene 1 (IRG1) is one of the highest induced genes in macrophages under pro-inflammatory conditions. Its function has been recently described: it codes for immune-responsive gene 1 protein/cis-aconitic acid decarboxylase (IRG1/CAD), an enzyme catalysing the production of itaconic acid from cis-aconitic acid, a tricarboxylic acid (TCA) cycle intermediate. Itaconic acid possesses specific antimicrobial properties inhibiting isocitrate lyase, the first enzyme of the glyoxylate shunt ...[more]