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Zfp281 Coordinates Opposite Functions of Tet1 and Tet2 for Alternative Pluripotent States

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Mus musculus

SUBMITTER: Jianlong Wang

PROVIDER: E-GEOD-81045 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Zfp281 Coordinates Opposing Functions of Tet1 and Tet2 in Pluripotent States.

Fidalgo Miguel M Huang Xin X Guallar Diana D Sanchez-Priego Carlos C Valdes Victor Julian VJ Saunders Arven A Ding Junjun J Wu Wen-Shu WS Clavel Carlos C Wang Jianlong J

Cell stem cell 20160623 3

Pluripotency is increasingly recognized as a spectrum of cell states defined by their growth conditions. Although naive and primed pluripotency states have been characterized molecularly, our understanding of events regulating state acquisition is wanting. Here, we performed comparative RNA sequencing of mouse embryonic stem cells (ESCs) and defined a pluripotent cell fate (PCF) gene signature associated with acquisition of naive and primed pluripotency. We identify Zfp281 as a key transcription ...[more]

PMID: 27345836

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