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Methotrexate resistant Leishmania strains

ABSTRACT: This SuperSeries is composed of the following subset Series: GSE9947: Transcriptional analysis of Leishmania infantum methotrexate resistant strains using full-genome DNA microarrays GSE9948: Transcriptional analysis of Leishmania major methotrexate resistant strains using full-genome DNA microarrays Keywords: SuperSeries Refer to individual Series

ORGANISM(S): Leishmania infantum

SUBMITTER: Marc Ouellette

PROVIDER: E-GEOD-9949 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Modulation of gene expression in drug resistant Leishmania is associated with gene amplification, gene deletion and chromosome aneuploidy.

Ubeda Jean-Michel JM Légaré Danielle D Raymond Frédéric F Ouameur Amin Ahmed AA Boisvert Sébastien S Rigault Philippe P Corbeil Jacques J Tremblay Michel J MJ Olivier Martin M Papadopoulou Barbara B Ouellette Marc M

Genome biology 20080718 7

<h4>Background</h4>Drug resistance can be complex, and several mutations responsible for it can co-exist in a resistant cell. Transcriptional profiling is ideally suited for studying complex resistance genotypes and has the potential to lead to novel discoveries. We generated full genome 70-mer oligonucleotide microarrays for all protein coding genes of the human protozoan parasites Leishmania major and Leishmania infantum. These arrays were used to monitor gene expression in methotrexate resist ...[more]

PMID: 18638379

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