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Transcription profiling of human seminiferous tubules from subfertile/infertile patients undergoing testicular sperm extraction as part of their treatment

ABSTRACT: 43 biopsies were obtained from subfertile/infertile patients undergoing testicular sperm extraction (TESE) as part of their treatment. Labelled cDNAs were compared to a reference normal testis RNA (Ambion).

INSTRUMENT(S): Axon-GenePix 4100A

ORGANISM(S): Homo sapiens

DISEASE(S): cryptozoospermia

SUBMITTER: Peter Ellis

PROVIDER: E-MEXP-1019 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Coordinated transcriptional regulation patterns associated with infertility phenotypes in men.

Ellis Peter J I PJ Furlong Robert A RA Conner Sarah J SJ Kirkman-Brown Jackson J Afnan Masoud M Barratt Christopher C Griffin Darren K DK Affara Nabeel A NA

Journal of medical genetics 20070511 8

<h4>Introduction</h4>Microarray gene-expression profiling is a powerful tool for global analysis of the transcriptional consequences of disease phenotypes. Understanding the genetic correlates of particular pathological states is important for more accurate diagnosis and screening of patients, and thus for suggesting appropriate avenues of treatment. As yet, there has been little research describing gene-expression profiling of infertile and subfertile men, and thus the underlying transcriptiona ...[more]

PMID: 17496197

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2007-07-06 | E-MEXP-1153 | biostudies-arrayexpress

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2008-06-26 | E-MEXP-1529 | biostudies-arrayexpress

Transcription profiling of T. brucei cell lines over-expressing wild type RAB5A or mutant versions of RAB5A or RAB5B locked in the GTP-bound state

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2008-06-26 | E-MEXP-1539 | biostudies-arrayexpress

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2008-06-26 | E-MEXP-1533 | biostudies-arrayexpress

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