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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Chico mutant

ABSTRACT: Comparison of wild type and heterozygote and homozygote chico mutants ( Clancy, et al. Extension of Life-Span by Loss of CHICO, a Drosophila Insulin Receptor Substrate Protein. Science 292 (5514), 104.) on Affymetrix Drosophila2 GeneChip. The flies (Drosophila melanogaster) are 7 day old adult females.

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Eugene Schuster

PROVIDER: E-MEXP-1099 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Evolutionary conservation of regulated longevity assurance mechanisms.

McElwee Joshua J JJ Schuster Eugene E Blanc Eric E Piper Matthew D MD Thomas James H JH Patel Dhaval S DS Selman Colin C Withers Dominic J DJ Thornton Janet M JM Partridge Linda L Gems David D

Genome biology 20070101 7

<h4>Background</h4>To what extent are the determinants of aging in animal species universal? Insulin/insulin-like growth factor (IGF)-1 signaling (IIS) is an evolutionarily conserved (public) regulator of longevity; yet it remains unclear whether the genes and biochemical processes through which IIS acts on aging are public or private (that is, lineage specific). To address this, we have applied a novel, multi-level cross-species comparative analysis to compare gene expression changes accompanyi ...[more]

PMID: 17612391

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