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Transcription profiling of tissues from chickens infected with Chicken Anaemia Virus CAV

ABSTRACT: Chicken anaemia virus (CAV) causes severe anaemia and immunosuppression in young chickens. Such effects reduce the efficiency of routine vaccinations while aggravating the effects of other pathogens in chicken populations. So far, the host responses to CAV have not been studied in vivo on a whole genome-wide scale. In this study, we compared gene expression profiles of chicken tissues (thymus, bone marrow, bursa of Fabricius and spleen-in vivo) from SPF chickens at 14-day-old following intramuscular inoculation at day-old. A chicken specific-immune microarray (5k) developed at Roslin Institute was used throughout the study. Statistically significant gene expression changes occurred mainly in the thymus (in vivo).

INSTRUMENT(S): ScanArray 5000 [PerkinElmer]

ORGANISM(S): Gallus gallus

DISEASE(S): mock infected

SUBMITTER: Mark Fell

PROVIDER: E-MEXP-1228 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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