Ontology highlight
ABSTRACT:
INSTRUMENT(S): ScanArray Express HT [PerkinElmer]
ORGANISM(S): Mus musculus
SUBMITTER: Michael Krause
PROVIDER: E-MEXP-1311 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
BMC cancer 20100721
<h4>Background</h4>Melanoma is an aggressive tumor with increasing incidence. To develop accurate prognostic markers and targeted therapies, changes leading to malignant transformation of melanocytes need to be understood. In the Xiphophorus melanoma model system, a mutated version of the EGF receptor Xmrk (Xiphophorus melanoma receptor kinase) triggers melanomagenesis. Cellular events downstream of Xmrk, such as the activation of Akt, Ras, B-Raf or Stat5, were also shown to play a role in human ...[more]