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Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of S. typhimurium during the intracellular growth phase of infection pathogenesis following infection of macrophages

ABSTRACT: DNA microarrays were used to provide a global transcriptional profile of S. typhimurium during the intracellular growth phase of infection pathogenesis following infection of macrophages.

ORGANISM(S): Salmonella enterica serovar Typhimurium

SUBMITTER: Mark Alston

PROVIDER: E-MEXP-415 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Unravelling the biology of macrophage infection by gene expression profiling of intracellular Salmonella enterica.

Eriksson Sofia S Lucchini Sacha S Thompson Arthur A Rhen Mikael M Hinton Jay C D JC

Molecular microbiology 20030101 1

For intracellular pathogens such as Salmonellae, Mycobacteriae and Brucellae, infection requires adaptation to the intracellular environment of the phagocytic cell. The transition from extracellular to intravacuolar environment has been expected to involve a global modulation of bacterial gene expression, but the precise events have been difficult to determine. We now report the complete transcriptional profile of intracellular Salmonella enterica sv. Typhimurium following macrophage infection. ...[more]

PMID: 12492857

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