Ontology highlight
ABSTRACT:
INSTRUMENT(S): GenePix 4000B [Axon Instruments]
ORGANISM(S): Homo sapiens
SUBMITTER: Idit Shiff
PROVIDER: E-MEXP-1501 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Shaked Helena H Shiff Idit I Kott-Gutkowski Miriam M Siegfried Zahava Z Haupt Ygal Y Simon Itamar I
Cancer research 20081201 23
The p53 tumor suppressor protein is a transcription factor that plays a key role in the cellular response to stress and cancer prevention. Upon activation, p53 regulates a large variety of genes causing cell cycle arrest, apoptosis, or senescence. We have developed a p53-focused array, which allows us to investigate, simultaneously, p53 interactions with most of its known target sequences using the chromatin immunoprecipitation (ChIP)-on-chip methodology. Applying this technique to multiple cell ...[more]