Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Idit Shiff
PROVIDER: E-MTAB-3362 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Laptenko Oleg O Shiff Idit I Freed-Pastor Will W Zupnick Andrew A Mattia Melissa M Freulich Ella E Shamir Inbal I Kadouri Noam N Kahan Tamar T Manfredi James J Simon Itamar I Prives Carol C
Molecular cell 20150301 6
DNA binding by numerous transcription factors including the p53 tumor suppressor protein constitutes a vital early step in transcriptional activation. While the role of the central core DNA binding domain (DBD) of p53 in site-specific DNA binding has been established, the contribution of the sequence-independent C-terminal domain (CTD) is still not well understood. We investigated the DNA-binding properties of a series of p53 CTD variants using a combination of in vitro biochemical analyses and ...[more]