Ontology highlight
ABSTRACT:
INSTRUMENT(S): Axon GenePix 4000B scanning hardware
ORGANISM(S): Mus musculus
SUBMITTER: Elizabeth Herbolsheimer
PROVIDER: E-WMIT-8 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Bioinformatics (Oxford, England) 20051206 4
<h4>Motivation</h4>Genome-wide chromatin-immunoprecipitation (ChIP-chip) detects binding of transcriptional regulators to DNA in vivo at low resolution. Motif discovery algorithms can be used to discover sequence patterns in the bound regions that may be recognized by the immunoprecipitated protein. However, the discovered motifs often do not agree with the binding specificity of the protein, when it is known.<h4>Results</h4>We present a powerful approach to analyzing ChIP-chip data, called THEM ...[more]