Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Carlos Moreno
PROVIDER: E-MEXP-156 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Moreno Carlos S CS Ramachandran Sumathi S Ashby Danita G DG Laycock Noelani N Plattner Courtney A CA Chen Wen W Hahn William C WC Pallas David C DC
Cancer research 20041001 19
One set of genes sufficient for transformation of primary human cells uses the combination of Ha-Ras-V12, the telomerase catalytic subunit hTERT, SV40 large tumor antigen (LT), and SV40 small tumor antigen (ST). Whereas SV40 LT inactivates the retinoblastoma protein and p53, the contribution of ST is poorly understood. The essential helper function of ST requires a functional interaction with protein phosphatase 2A (PP2A). Here we have identified changes in gene expression induced by ST and show ...[more]