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Transcription profiling of human serum starvation cell lines for 24hrs, 4 cell types - TERV, TERV-ST, TERV-ST110, TERV-ASB56

ABSTRACT: Study the effects of serum starvation for 24hrs on 4 cell types - TERV, TERV-ST, TERV-ST110, TERV-ASB56.

ORGANISM(S): Homo sapiens

SUBMITTER: Carlos Moreno

PROVIDER: E-MEXP-156 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Signaling and transcriptional changes critical for transformation of human cells by simian virus 40 small tumor antigen or protein phosphatase 2A B56gamma knockdown.

Moreno Carlos S CS Ramachandran Sumathi S Ashby Danita G DG Laycock Noelani N Plattner Courtney A CA Chen Wen W Hahn William C WC Pallas David C DC

Cancer research 20041001 19

One set of genes sufficient for transformation of primary human cells uses the combination of Ha-Ras-V12, the telomerase catalytic subunit hTERT, SV40 large tumor antigen (LT), and SV40 small tumor antigen (ST). Whereas SV40 LT inactivates the retinoblastoma protein and p53, the contribution of ST is poorly understood. The essential helper function of ST requires a functional interaction with protein phosphatase 2A (PP2A). Here we have identified changes in gene expression induced by ST and show ...[more]

PMID: 15466190

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