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Transcription profiling of Candida albicans wild type and mnl1 cells after treatment with acetic acid

ABSTRACT: Wt vs mnl1 cells after 300 min treatment with 20 mM acetic acid in SC-pH3.0

ORGANISM(S): Candida albicans

SUBMITTER: Mark Ramsdale

PROVIDER: E-MEXP-1641 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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MNL1 regulates weak acid-induced stress responses of the fungal pathogen Candida albicans.

Ramsdale Mark M Selway Laura L Stead David D Walker Jan J Yin Zhikang Z Nicholls Susan M SM Crowe Jonathan J Sheils Emma M EM Brown Alistair J P AJ

Molecular biology of the cell 20080723 10

MNL1, the Candida albicans homologue of an orphan Msn2-like gene (YER130c in Saccharomyces cerevisiae) has no known function. Here we report that MNL1 regulates weak acid stress responses. Deletion of MNL1 prevents the long-term adaptation of C. albicans cells to weak acid stresses and compromises their global transcriptional response under these conditions. The promoters of Mnl1-dependent genes contain a novel STRE-like element (SLE) that imposes Mnl1-dependent, weak acid stress-induced transcr ...[more]

PMID: 18653474

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