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Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of Candida albicans wildtype and hsf1 mutant cells after heatstress

ABSTRACT: effect of heatstress on wildtype and hsf1 mutant cells

ORGANISM(S): Candida albicans

SUBMITTER: AFG AFG

PROVIDER: E-MEXP-2044 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Role of the heat shock transcription factor, Hsf1, in a major fungal pathogen that is obligately associated with warm-blooded animals.

Nicholls Susan S Leach Michelle D MD Priest Claire L CL Brown Alistair J P AJ

Molecular microbiology 20091008 4

All organisms have evolved mechanisms that protect them against environmental stress. The major fungal pathogen of humans, Candida albicans, has evolved robust stress responses that protect it against human immune defences and promote its pathogenicity. However, C. albicans is unlikely to be exposed to heat shock as it is obligatorily associated with warm-blooded animals. Therefore, we examined the role of the heat shock transcription factor (Hsf1) in this pathogen. We show that C. albicans expr ...[more]

PMID: 19818013

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