Dataset Information
Transcription profiling time series of Candida albicans treated with different doses of acetic acid
Ontology highlight
ABSTRACT:
mM acetic acid. Cells were harvested after zero, 10, 30, 60, 120, 210 and 300 min treatment. RNA isolated from triplicate biological replicates were compared with a standard pooled control (untreated cells).
ORGANISM(S): Candida albicans
SUBMITTER: Mark Ramsdale
PROVIDER: E-MEXP-1645 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
MNL1 regulates weak acid-induced stress responses of the fungal pathogen Candida albicans.
Molecular biology of the cell 20080723 10
MNL1, the Candida albicans homologue of an orphan Msn2-like gene (YER130c in Saccharomyces cerevisiae) has no known function. Here we report that MNL1 regulates weak acid stress responses. Deletion of MNL1 prevents the long-term adaptation of C. albicans cells to weak acid stresses and compromises their global transcriptional response under these conditions. The promoters of Mnl1-dependent genes contain a novel STRE-like element (SLE) that imposes Mnl1-dependent, weak acid stress-induced transcr ...[more]
