Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of rat colonic tumors induced by 1,2-dimethylhydrazine (DMH)


ABSTRACT: Gene expression analysis of 1,2-dimethylhydrazine (DMH)-induced colon cancer in F344 rats. 9 tumours and their paired normal mucosa were hybridized on 4x44K Agilent Whole rat arrays.

ORGANISM(S): Rattus norvegicus

DISEASE(S): normal

SUBMITTER: Cristina Luceri 

PROVIDER: E-MEXP-2471 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Gene expression profile and genomic alterations in colonic tumours induced by 1,2-dimethylhydrazine (DMH) in rats.

Femia Angelo Pietro AP   Luceri Cristina C   Toti Simona S   Giannini Augusto A   Dolara Piero P   Caderni Giovanna G  

BMC cancer 20100511


<h4>Background</h4>Azoxymethane (AOM) or 1,2-dimethylhydrazine (DMH)-induced colon carcinogenesis in rats shares many phenotypical similarities with human sporadic colon cancer and is a reliable model for identifying chemopreventive agents. Genetic mutations relevant to human colon cancer have been described in this model, but comprehensive gene expression and genomic analysis have not been reported so far. Therefore, we applied genome-wide technologies to study variations in gene expression and  ...[more]

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