Ontology highlight
ABSTRACT:
ORGANISM(S): Rattus norvegicus
DISEASE(S): normal
SUBMITTER: Cristina Luceri
PROVIDER: E-MEXP-2471 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Femia Angelo Pietro AP Luceri Cristina C Toti Simona S Giannini Augusto A Dolara Piero P Caderni Giovanna G
BMC cancer 20100511
<h4>Background</h4>Azoxymethane (AOM) or 1,2-dimethylhydrazine (DMH)-induced colon carcinogenesis in rats shares many phenotypical similarities with human sporadic colon cancer and is a reliable model for identifying chemopreventive agents. Genetic mutations relevant to human colon cancer have been described in this model, but comprehensive gene expression and genomic analysis have not been reported so far. Therefore, we applied genome-wide technologies to study variations in gene expression and ...[more]