Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of rat colon tumors induced by DMH

ABSTRACT: 344 rats were treated twice, one week apart, with subcutaneous injections of 1,2-dimethylhydrazine (150 mg/kg x 2). Thirty-two weeks after the first DMH injection, rats were sacrificed and colonic tumours (T) and normal colon mucosa (NM) harvested and stored in RNAlater. Genomic DNA was extracted from ten samples of paired T and NM and hybridized on Agilent Rat Genome CGH Microarray 2x105K.

ORGANISM(S): Rattus norvegicus

DISEASE(S): normal

SUBMITTER: Cristina Luceri 

PROVIDER: E-MEXP-2487 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Gene expression profile and genomic alterations in colonic tumours induced by 1,2-dimethylhydrazine (DMH) in rats.

Femia Angelo Pietro AP   Luceri Cristina C   Toti Simona S   Giannini Augusto A   Dolara Piero P   Caderni Giovanna G  

BMC cancer 20100511

<h4>Background</h4>Azoxymethane (AOM) or 1,2-dimethylhydrazine (DMH)-induced colon carcinogenesis in rats shares many phenotypical similarities with human sporadic colon cancer and is a reliable model for identifying chemopreventive agents. Genetic mutations relevant to human colon cancer have been described in this model, but comprehensive gene expression and genomic analysis have not been reported so far. Therefore, we applied genome-wide technologies to study variations in gene expression and  ...[more]

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