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MicroRNA profiling of human neuroblastoma cells shows MYCN-regulated MicroRNAs repress estrogen receptor-alpha expression

ABSTRACT: Effect of MYCN expression on microRNA transcriptome in human neuroblastoma.

ORGANISM(S): Homo sapiens

SUBMITTER: Jakob Lovén

PROVIDER: E-MEXP-2006 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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MYCN-regulated microRNAs repress estrogen receptor-alpha (ESR1) expression and neuronal differentiation in human neuroblastoma.

Lovén Jakob J Zinin Nikolay N Wahlström Therese T Müller Inga I Brodin Petter P Fredlund Erik E Ribacke Ulf U Pivarcsi Andor A Påhlman Sven S Henriksson Marie M

Proceedings of the National Academy of Sciences of the United States of America 20100104 4

MYCN, a proto-oncogene normally expressed in the migrating neural crest, is in its amplified state a key factor in the genesis of human neuroblastoma (NB). However, the mechanisms underlying MYCN-mediated NB progression are poorly understood. Here, we present a MYCN-induced miRNA signature in human NB involving the activation and transrepression of several miRNA genes from paralogous clusters. Several family members derived from the miR-17 approximately 92 cluster, including miR-18a and miR-19a, ...[more]

PMID: 20080637

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