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MicroRNA profiling of human precursor B-cell acute lymphoblastic leukemia cell line NALM-6 after trichostatin A treatment

ABSTRACT: Expression profile of miRNAs in NALM-6 cells were analyzed after TSA treatment for 6h, compared with non-treated cells.

ORGANISM(S): Homo sapiens

SUBMITTER: Xian-Ming Chen 

PROVIDER: E-MEXP-2047 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Gene silencing of MIR22 in acute lymphoblastic leukaemia involves histone modifications independent of promoter DNA methylation.

Li Xiaoqing X   Liu Jun J   Zhou Rui R   Huang Shi S   Huang Shiang S   Chen Xian-Ming XM  

British journal of haematology 20091005 1

Aberrant epigenetic regulation has recently been implicated in the downregulation of tumour suppressor microRNAs (miRNAs). Histone modification and DNA methylation can have different roles in gene silencing in cancer. To investigate whether histone modifications would contribute to the dysregulation of miRNAs in acute lymphoblastic leukaemia (ALL), the effect of a histone deacetylase inhibitor, trichostatin A (TSA), on miRNA expression profile was analysed by microarray assay in a precursor B-ce  ...[more]

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