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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of human fetal gammadelta T cells from that cytomegalovirus (CMV) positive or negative

ABSTRACT: Response of fetal gammadelta T cells towards infection with human cytomegalovirus (CMV)

ORGANISM(S): Homo sapiens

SUBMITTER: David Vermijlen

PROVIDER: E-MEXP-2055 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Human cytomegalovirus elicits fetal gammadelta T cell responses in utero.

Vermijlen David D Brouwer Margreet M Donner Catherine C Liesnard Corinne C Tackoen Marie M Van Rysselberge Michel M Twité Nicolas N Goldman Michel M Marchant Arnaud A Willems Fabienne F

The Journal of experimental medicine 20100405 4

The fetus and infant are highly susceptible to viral infections. Several viruses, including human cytomegalovirus (CMV), cause more severe disease in early life compared with later life. It is generally accepted that this is a result of the immaturity of the immune system. gammadelta T cells are unconventional T cells that can react rapidly upon activation and show major histocompatibility complex-unrestricted activity. We show that upon CMV infection in utero, fetal gammadelta T cells expand an ...[more]

PMID: 20368575

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