Ontology highlight
ABSTRACT:
ORGANISM(S): Streptomyces coelicolor
SUBMITTER: Antonio RodrM-mguez-GarcM-ma
PROVIDER: E-MEXP-2132 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
PloS one 20120220 2
LAL regulators (Large ATP-binding regulators of the LuxR family) constitute a poorly studied family of transcriptional regulators. Several regulators of this class have been identified in antibiotic and other secondary metabolite gene clusters from actinomycetes, thus they have been considered pathway-specific regulators. In this study we have obtained two disruption mutants of LAL genes from S. coelicolor (Δ0877 and Δ7173). Both mutants were deficient in the production of the polyketide antibio ...[more]