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Transcription profiling of mouse model for the metabolic effects of the human fat mass and obesity associated fto gene

ABSTRACT: RNA was purified from liver, skeletal muscle and white adipose tissue of mice with and without a point mutation in exon 6 of the FTO gene.

ORGANISM(S): Mus musculus

SUBMITTER: Sheena Lee

PROVIDER: E-MEXP-2201 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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A mouse model for the metabolic effects of the human fat mass and obesity associated FTO gene.

Church Chris C Lee Sheena S Bagg Eleanor A L EA McTaggart James S JS Deacon Robert R Gerken Thomas T Lee Angela A Moir Lee L Mecinović Jasmin J Quwailid Mohamed M MM Schofield Christopher J CJ Ashcroft Frances M FM Cox Roger D RD

PLoS genetics 20090814 8

Human FTO gene variants are associated with body mass index and type 2 diabetes. Because the obesity-associated SNPs are intronic, it is unclear whether changes in FTO expression or splicing are the cause of obesity or if regulatory elements within intron 1 influence upstream or downstream genes. We tested the idea that FTO itself is involved in obesity. We show that a dominant point mutation in the mouse Fto gene results in reduced fat mass, increased energy expenditure, and unchanged physical ...[more]

PMID: 19680540

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