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Transcription profiling of human endothelial cells UPR signature and concomitant activation of multiple signaling pathways in cells exposed to hGX sPLA2 modified LDL

ABSTRACT: We conducted a global transcriptional profiling using microarray analysis of the response of EC exposed either to native LDL or LDL-X

ORGANISM(S): Homo sapiens

SUBMITTER: Seraya Maouche 

PROVIDER: E-MEXP-2256 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Phospholipolyzed LDL induces an inflammatory response in endothelial cells through endoplasmic reticulum stress signaling.

Gora Sarah S   Maouche Seraya S   Atout Rajai R   Wanherdrick Kristell K   Lambeau Gérard G   Cambien François F   Ninio Ewa E   Karabina Sonia-Athina SA  

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20100429 9

Secreted phospholipases A2 (sPLA2s) are present in atherosclerotic plaques and are now considered novel attractive therapeutic targets and potential biomarkers as they contribute to the development of atherosclerosis through lipoprotein-dependent and independent mechanisms. We have previously shown that hGX-sPLA2-phospholipolyzed LDL (LDL-X) induces proinflammatory responses in human umbilical endothelial cells (HUVECs); here we explore the molecular mechanisms involved. Global transcriptional g  ...[more]

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