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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Insights into salt-sensitive hypertension using response-relevant clustering

ABSTRACT: Compare effects of salt in salt sensitive, salt resistant and congenic rat strains. There were 6 groups of animals: SHRSP salt-loaded, SHRSP, SP.WKYGla2a salt-loaded, SP.WKYGla2a, WKY salt-loaded, WKY, , The salt loaded animals had 1% salt added to their drinking water at 18 weeks of age. Non treated animals were not supplied with salt. All animals were sacrificed, by overdose of anaesthetic and exsaguination, at 21 weeks of age and tissues snap frozen in liquid N2. Tissues were removed to -70 degrees C for storage.

ORGANISM(S): Rattus norvegicus

SUBMITTER: Martin McBride

PROVIDER: E-MEXP-2514 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Predictive response-relevant clustering of expression data provides insights into disease processes.

Hopcroft Lisa E M LE McBride Martin W MW Harris Keith J KJ Sampson Amanda K AK McClure John D JD Graham Delyth D Young Graham G Holyoake Tessa L TL Girolami Mark A MA Dominiczak Anna F AF

Nucleic acids research 20100622 20

This article describes and illustrates a novel method of microarray data analysis that couples model-based clustering and binary classification to form clusters of `response-relevant' genes; that is, genes that are informative when discriminating between the different values of the response. Predictions are subsequently made using an appropriate statistical summary of each gene cluster, which we call the `meta-covariate' representation of the cluster, in a probit regression model. We first illus ...[more]

PMID: 20571087

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