Transcription profiling of human primary CD30+/CD38lo cells differentiating along the megakaryocyte lineage
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Mi-Hyun Shim
PROVIDER: E-MEXP-70 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Gene expression profile of primary human CD34+CD38lo cells differentiating along the megakaryocyte lineage.
Shim Mi-Hyun MH Hoover Aubree A Blake Noel N Drachman Jonathan G JG Reems Jo Anna JA
Experimental hematology 20040701 7
<h4>Objective</h4>To identify genes involved in megakaryopoiesis, high-density oligonucleotide microarrays were used to compare transcript profiles from undifferentiated CD34+CD38lo cells and culture-derived megakaryocytes (MKs).<h4>Materials and methods</h4>Megakaryocyte differentiation was achieved in vitro by inducing primary human CD34+CD38lo cells in serum-deprived media supplemented with the cytokine combination of interleukin-3, interleukin-6, stem cell factor, and thrombopoietin for 10 d ...[more]
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