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Genotyping by array of human neuroblastoma cell lines showing MYCN amplification as double minutes or homogeneously staining regions

ABSTRACT: SNP array profile of cell lines from solid tumors showing MYCN amplification as Double minutes (dmin) and homogeneously staining regions (hsr)

ORGANISM(S): Homo sapiens

SUBMITTER: Massimo Carella

PROVIDER: E-MEXP-2735 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Gene amplification as double minutes or homogeneously staining regions in solid tumors: origin and structure.

Storlazzi Clelia Tiziana CT Lonoce Angelo A Guastadisegni Maria C MC Trombetta Domenico D D'Addabbo Pietro P Daniele Giulia G L'Abbate Alberto A Macchia Gemma G Surace Cecilia C Kok Klaas K Ullmann Reinhard R Purgato Stefania S Palumbo Orazio O Carella Massimo M Ambros Peter F PF Rocchi Mariano M

Genome research 20100714 9

Double minutes (dmin) and homogeneously staining regions (hsr) are the cytogenetic hallmarks of genomic amplification in cancer. Different mechanisms have been proposed to explain their genesis. Recently, our group showed that the MYC-containing dmin in leukemia cases arise by excision and amplification (episome model). In the present paper we investigated 10 cell lines from solid tumors showing MYCN amplification as dmin or hsr. Particularly revealing results were provided by the two subclones ...[more]

PMID: 20631050

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