Unknown,Transcriptomics,Genomics,Proteomics

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Deciphering the role of RND efflux transporters in Burkholderia cenocepacia D9 and D4-D9


ABSTRACT: To compare the expression profile of B. cenocepacia mutants impaired in RND efflux pump encoding genes

ORGANISM(S): Burkholderia cenocepacia

SUBMITTER: Silvia Bazzini 

PROVIDER: E-MEXP-2997 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications


Burkholderia cenocepacia J2315 is representative of a highly problematic group of cystic fibrosis (CF) pathogens. Eradication of B. cenocepacia is very difficult with the antimicrobial therapy being ineffective due to its high resistance to clinically relevant antimicrobial agents and disinfectants. RND (Resistance-Nodulation-Cell Division) efflux pumps are known to be among the mediators of multidrug resistance in gram-negative bacteria. Since the significance of the 16 RND efflux systems prese  ...[more]

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