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Response of Streptomyces coelicolor to treatment with the antibiotics vancomycin bacitracin and moenomycin A

ABSTRACT: To determine the response at the transcriptional level of S. coelicolor cells to treatment with 3 antibiotics that target distinct stages of cell wall biosynthesis, biological triplicate cultures of strain M600 were treated with sub-lethal concentrations (10 µg/ml) of vancomycin, bacitracin or moenomycin A. Samples were taken 0, 30, 60, 90 minutes after addition of the antibiotic. A negative control which received no drug treatment was also performed.

ORGANISM(S): Streptomyces coelicolor A3(2)

SUBMITTER: Andrew Hesketh

PROVIDER: E-MEXP-3032 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Genome-wide dynamics of a bacterial response to antibiotics that target the cell envelope.

Hesketh Andy A Hill Chris C Mokhtar Jehan J Novotna Gabriela G Tran Ngat N Bibb Mervyn M Hong Hee-Jeon HJ

BMC genomics 20110511

<h4>Background</h4>A decline in the discovery of new antibacterial drugs, coupled with a persistent rise in the occurrence of drug-resistant bacteria, has highlighted antibiotics as a diminishing resource. The future development of new drugs with novel antibacterial activities requires a detailed understanding of adaptive responses to existing compounds. This study uses Streptomyces coelicolor A3(2) as a model system to determine the genome-wide transcriptional response following exposure to thr ...[more]

PMID: 21569315

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