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Transcription profiling of human colon cancer cell lines

ABSTRACT: Assess the full impact of estrogen receptor beta on transcription by a full transcriptome analysis of ERb-mediated gene regulation in the two colon cancer cell lines HCT116 and HT29. The colon cancer cell lines do not express endogenous ER but is made ERb-expressing by lentiviral transduction of an ERb expression cassette. Introduction of ERb makes it possible to study the role and function of ERb in colon cancer as well as the impact ERb has on its own (in the absence of ERa).

ORGANISM(S): Homo sapiens

DISEASE(S): colorectal carcinoma

SUBMITTER: Karin Edvardsson

PROVIDER: E-MEXP-3169 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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