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Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of breast cancer cells with TET-OFF regulated ERb expression treated with estradiol or ICI, an estrogen receptor antagonist

ABSTRACT: Assess the full impact of estrogen receptor beta on transcription by a full transcriptome analysis of ERa and ERb-mediated gene regulation in T47D breast cancer cell line with TET-OFF regulated ERb expression.

INSTRUMENT(S): G2565BA DNA microarray scanner [Agilent]

ORGANISM(S): Homo sapiens

DISEASE(S): breast cancer

SUBMITTER: Cecilia Williams

PROVIDER: E-MEXP-969 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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A genome-wide study of the repressive effects of estrogen receptor beta on estrogen receptor alpha signaling in breast cancer cells.

Williams C C Edvardsson K K Lewandowski S A SA Ström A A Gustafsson J-A JA

Oncogene 20070813 7

Transcriptional effects of estrogen result from its activation of two estrogen receptor (ER) isoforms; ERalpha that drives proliferation and ERbeta that is antiproliferative. Expression of ERbeta in xenograft tumors from the T47D breast cancer cell line reduces tumor growth and angiogenesis. If ERbeta can halt tumor growth, its introduction into cancers may be a novel therapeutic approach to the treatment of estrogen-responsive cancers. To assess the complete impact of ERbeta on transcription, w ...[more]

PMID: 17700529

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