Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
DISEASE(S): colorectal carcinoma
SUBMITTER: Elisabeth Naschberger
PROVIDER: E-MEXP-3188 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Serafin Valentina V Persano Luca L Moserle Lidia L Esposito Giovanni G Ghisi Margherita M Curtarello Matteo M Bonanno Laura L Masiero Massimo M Ribatti Domenico D Stürzl Michael M Naschberger Elisabeth E Croner Roland S RS Jubb Adrian M AM Harris Adrian L AL Koeppen Hartmut H Amadori Alberto A Indraccolo Stefano S
The Journal of pathology 20110519 4
Increased Notch1 activity has been observed in intestinal tumours, partially accomplished by β-catenin-mediated up-regulation of the Notch ligand Jagged-1. Whether further mechanisms of Notch activation exist and other Notch receptors might be involved is unclear. Microarray data indicated that Notch3 transcript levels are significantly up-regulated in primary and metastatic CRC samples compared to normal mucosa. Moreover, Notch3 protein was expressed at strong/moderate levels by 19.7% of 158 CR ...[more]