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Biofilm development in B. bronchiseptica

ABSTRACT: To identify global stage-specific gene sets unique to biofilm formation for B. bronchiseptica, whole-genome transcriptome analysis was used to measure mRNA abundance under biofilm and planktonic growth conditions after 6, 12, 24, 36, and 48 hours of growth.

ORGANISM(S): Bordetella bronchiseptica

SUBMITTER: Tracy Nicholson

PROVIDER: E-MEXP-3295 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Transcriptome profiling reveals stage-specific production and requirement of flagella during biofilm development in Bordetella bronchiseptica.

Nicholson Tracy L TL Conover Matt S MS Deora Rajendar R

PloS one 20121112 11

We have used microarray analysis to study the transcriptome of the bacterial pathogen Bordetella bronchiseptica over the course of five time points representing distinct stages of biofilm development. The results suggest that B. bronchiseptica undergoes a coordinately regulated gene expression program similar to a bacterial developmental process. Expression and subsequent production of the genes encoding flagella, a classical Bvg(-) phase phenotype, occurs and is under tight regulatory control d ...[more]

PMID: 23152870

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