Dataset Information
Genomic profiling of high-risk diffuse large B-cell lymphoma patients treated with dose-dense chemoimmunotherapy
Ontology highlight
ABSTRACT:
51 prospectively collected tumor samples from the patients treated in the Nordic phase II study with dose-dense chemoimmunotherapy followed by systemic CNS prophylaxis were analyzed by high resolution array comparative genomic hybridization (aCGH).
The aCGH data were combined with the transcriptomics information from the exon array and the data associated with survival.
ORGANISM(S): Homo sapiens
DISEASE(S): diffuse large B-cell lymphoma
SUBMITTER: Minna Taskinen
PROVIDER: E-MEXP-3463 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Deregulation of COMMD1 is associated with poor prognosis in diffuse large B-cell lymphoma.
PloS one 20140313 3
<h4>Background</h4>Despite improved survival for the patients with diffuse large B-cell lymphoma (DLBCL), the prognosis after relapse is poor. The aim was to identify molecular events that contribute to relapse and treatment resistance in DLBCL.<h4>Methods</h4>We analysed 51 prospectively collected pretreatment tumour samples from clinically high risk patients treated in a Nordic phase II study with dose-dense chemoimmunotherapy and central nervous system prophylaxis with high resolution array c ...[more]
