Dataset Information
MicroRNA155 mediates adverse inflammation in acute viral myocarditis LNA-antimiR155 treatment
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
DISEASE(S): viral myocarditis
SUBMITTER: Maarten Corsten
PROVIDER: E-MEXP-3395 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
MicroRNA profiling identifies microRNA-155 as an adverse mediator of cardiac injury and dysfunction during acute viral myocarditis.
Circulation research 20120619 4
<h4>Rationale</h4>Viral myocarditis results from an adverse immune response to cardiotropic viruses, which causes irreversible myocyte destruction and heart failure in previously healthy people. The involvement of microRNAs and their usefulness as therapeutic targets in this process are unknown.<h4>Objective</h4>To identify microRNAs involved in viral myocarditis pathogenesis and susceptibility.<h4>Methods and results</h4>Cardiac microRNAs were profiled in both human myocarditis and in Coxsackie ...[more]
