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Kolsto-Bacillus cereus transcriptional response of ATCC14579 BC4707 mutant to bile salts stress

ABSTRACT: Analysis of the transcriptional response of B. cereus ATCC14579 BC4707 deletion mutant after 15 min bile salts stress

ORGANISM(S): Bacillus cereus

SUBMITTER: Roger Simm

PROVIDER: E-MEXP-3536 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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BC4707 is a major facilitator superfamily multidrug resistance transport protein from Bacillus cereus implicated in fluoroquinolone tolerance.

Simm Roger R Vörös Aniko A Ekman Jaakko V JV Sødring Marianne M Nes Ingerid I Kroeger Jasmin K JK Saidijam Massoud M Bettaney Kim E KE Henderson Peter J F PJ Salkinoja-Salonen Mirja M Kolstø Anne-Brit AB

PloS one 20120516 5

Transcriptional profiling highlighted a subset of genes encoding putative multidrug transporters in the pathogen Bacillus cereus that were up-regulated during stress produced by bile salts. One of these multidrug transporters (BC4707) was selected for investigation. Functional characterization of the BC4707 protein in Escherichia coli revealed a role in the energized efflux of xenobiotics. Phenotypic analyses after inactivation of the gene bc4707 in Bacillus cereus ATCC14579 suggested a more spe ...[more]

PMID: 22615800

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