Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Kolsto-B. cereus Comparison of WT and BC4707 mutant during growth in logarithmic phase


ABSTRACT: Comparison of B. cereus ATCC14579 wild type and its isogenic BC4707 mutant under growth in logarithmic phase

ORGANISM(S): Bacillus cereus

SUBMITTER: Roger Simm 

PROVIDER: E-MEXP-3537 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

altmetric image

Publications

BC4707 is a major facilitator superfamily multidrug resistance transport protein from Bacillus cereus implicated in fluoroquinolone tolerance.

Simm Roger R   Vörös Aniko A   Ekman Jaakko V JV   Sødring Marianne M   Nes Ingerid I   Kroeger Jasmin K JK   Saidijam Massoud M   Bettaney Kim E KE   Henderson Peter J F PJ   Salkinoja-Salonen Mirja M   Kolstø Anne-Brit AB  

PloS one 20120516 5


Transcriptional profiling highlighted a subset of genes encoding putative multidrug transporters in the pathogen Bacillus cereus that were up-regulated during stress produced by bile salts. One of these multidrug transporters (BC4707) was selected for investigation. Functional characterization of the BC4707 protein in Escherichia coli revealed a role in the energized efflux of xenobiotics. Phenotypic analyses after inactivation of the gene bc4707 in Bacillus cereus ATCC14579 suggested a more spe  ...[more]

Similar Datasets

2012-01-31 | E-MEXP-3536 | biostudies-arrayexpress
2012-01-31 | E-MEXP-3535 | biostudies-arrayexpress
2012-01-31 | E-MEXP-3529 | biostudies-arrayexpress
2012-01-01 | E-MEXP-2790 | biostudies-arrayexpress
2013-04-04 | E-MEXP-3811 | biostudies-arrayexpress
2012-01-01 | E-MEXP-2754 | biostudies-arrayexpress
2012-01-01 | E-MEXP-2789 | biostudies-arrayexpress
2013-09-10 | E-MEXP-3894 | biostudies-arrayexpress
2012-01-01 | E-MEXP-2791 | biostudies-arrayexpress
2012-01-01 | E-MEXP-2787 | biostudies-arrayexpress