Gene expression profiling of CD4 T cells in treatment-naive HIV
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ABSTRACT: In this study, treatment-naive HIV, HCV mono-/co-infected individuals with CD4+ T cell counts >300/?l were recruited and their global gene expression profiles were investigated. By gene set enrichment analysis (GSEA), we revealed that gene sets of cell cycle progression, innate immune response and some transcription factors in CD4+ T cells were affected mainly by HIV; while genes associated with extracellular matrix (ECM), Beta cell development and insulin synthesis and secretion were the major targets of HCV. For metabolic pathways, it was modulated by both viruses. Besides, for the first time, our data uncovered the importance of GPCR signaling pathway during HCV, HIV infections. These data for the first time offer genetic basis for HCV/HIV mono-/co- infections, which will facilitate the understanding of the interaction of HCV/HIV in vivo and how they subvert the human gene machinery at the individual cell type level.
ORGANISM(S): Homo sapiens
DISEASE(S): HIV
SUBMITTER: lina yi
PROVIDER: E-MEXP-3601 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
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