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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling by array of mouse C2C12 muscle cells overexpressing PGC-1alpha, PGC-1beta or GFP to investigate differential expression of TNFalpha-induced genes

ABSTRACT: Differentiated C2C12 cells adenovirally overexpressing either PGC-1alpha or PGC-1beta or GFP as control were treated with TNFalpha for 2h or left untreated. NF-kappaB- and stress-depedent gene expression was determined by a customized array.

ORGANISM(S): Mus musculus

SUBMITTER: Christoph Handschin

PROVIDER: E-MEXP-3676 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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The peroxisome proliferator-activated receptor γ coactivator 1α/β (PGC-1) coactivators repress the transcriptional activity of NF-κB in skeletal muscle cells.

Eisele Petra S PS Salatino Silvia S Sobek Jens J Hottiger Michael O MO Handschin Christoph C

The Journal of biological chemistry 20121208 4

A persistent, low-grade inflammation accompanies many chronic diseases that are promoted by physical inactivity and improved by exercise. The beneficial effects of exercise are mediated in large part by peroxisome proliferator-activated receptor γ coactivator (PGC) 1α, whereas its loss correlates with propagation of local and systemic inflammatory markers. We examined the influence of PGC-1α and the related PGC-1β on inflammatory cytokines upon stimulation of muscle cells with TNFα, Toll-like re ...[more]

PMID: 23223635

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