Dataset Information
Sumoylation at Chromatin Governs Coordinated Repression of a Transcriptionnal Program Essential for Cell Growth and Proliferation 3
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: guillaume soubigou
PROVIDER: E-MEXP-3778 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Sumoylation at chromatin governs coordinated repression of a transcriptional program essential for cell growth and proliferation.
Genome research 20130726 10
Despite numerous studies on specific sumoylated transcriptional regulators, the global role of SUMO on chromatin in relation to transcription regulation remains largely unknown. Here, we determined the genome-wide localization of SUMO1 and SUMO2/3, as well as of UBC9 (encoded by UBE2I) and PIASY (encoded by PIAS4), two markers for active sumoylation, along with Pol II and histone marks in proliferating versus senescent human fibroblasts together with gene expression profiling. We found that, whe ...[more]
