Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Sumoylation at Chromatin Governs Coordinated Repression of a Transcriptionnal Program Essential for Cell Growth and Proliferation 2

ABSTRACT: mRNA profiling of proliferative versus Ras-induced senescent human primary fibroblasts 5 days post-infection. The goals of this study is to analyse transcriptional changes in senescent cells (RASv12 infected cells)

ORGANISM(S): Homo sapiens

SUBMITTER: guillaume soubigou 

PROVIDER: E-MEXP-3777 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Sumoylation at chromatin governs coordinated repression of a transcriptional program essential for cell growth and proliferation.

Neyret-Kahn Hélène H   Benhamed Moussa M   Ye Tao T   Le Gras Stéphanie S   Cossec Jack-Christophe JC   Lapaquette Pierre P   Bischof Oliver O   Ouspenskaia Maia M   Dasso Mary M   Seeler Jacob J   Davidson Irwin I   Dejean Anne A  

Genome research 20130726 10

Despite numerous studies on specific sumoylated transcriptional regulators, the global role of SUMO on chromatin in relation to transcription regulation remains largely unknown. Here, we determined the genome-wide localization of SUMO1 and SUMO2/3, as well as of UBC9 (encoded by UBE2I) and PIASY (encoded by PIAS4), two markers for active sumoylation, along with Pol II and histone marks in proliferating versus senescent human fibroblasts together with gene expression profiling. We found that, whe  ...[more]

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