Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Acquisition of docetaxel resistance in breast cancer cells reveals upregulation of ABCB1 expression as a key mediator of resistance accompanied by discrete upregulation of other specific genes and pathways”

ABSTRACT: Two breast cancer cell lines, MCF-7 and MDA-MB-213, were treated progressively with docetaxel.

ORGANISM(S): Homo sapiens

SUBMITTER: David Westergaard 

PROVIDER: E-MEXP-3982 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Acquisition of docetaxel resistance in breast cancer cells reveals upregulation of ABCB1 expression as a key mediator of resistance accompanied by discrete upregulation of other specific genes and pathways.

Hansen Stine Ninel SN   Westergaard David D   Thomsen Mathilde Borg Houlberg MB   Vistesen Mette M   Do Khoa Nguyen KN   Fogh Louise L   Belling Kirstine C KC   Wang Jun J   Yang Huanming H   Gupta Ramneek R   Ditzel Henrik J HJ   Moreira José J   Brünner Nils N   Stenvang Jan J   Schrohl Anne-Sofie AS  

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 20150118 6

The microtubule-targeting taxanes are important in breast cancer therapy, but no predictive biomarkers have yet been identified with sufficient scientific evidence to allow clinical routine use. The purposes of the present study were to develop a cell-culture-based discovery platform for docetaxel resistance and thereby identify key molecular mechanisms and predictive molecular characteristics to docetaxel resistance. Two docetaxel-resistant cell lines, MCF7RES and MDARES, were generated from th  ...[more]

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