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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Gene expression profile of corona radiata cells of individual MII oocytes developing into top quality embryos

ABSTRACT: Females suffering from Polycystic Ovary Syndrome (PCOS) were compared with non-PCOS females

ORGANISM(S): Homo sapiens

SUBMITTER: David Westergaard

PROVIDER: E-MEXP-3985 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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The transcriptome of corona radiata cells from individual MІІ oocytes that after ICSI developed to embryos selected for transfer: PCOS women compared to healthy women.

Wissing Marie Louise ML Sonne Si Brask SB Westergaard David D Nguyen Kho do Kd Belling Kirstine K Høst Thomas T Mikkelsen Anne Lis AL

Journal of ovarian research 20141129

<h4>Background</h4>Corona radiata cells (CRCs) refer to the fraction of cumulus cells just adjacent to the oocyte. The CRCs are closely connected to the oocyte throughout maturation and their gene expression profiles might reflect oocyte quality. Polycystic ovary syndrome (PCOS) is a common cause of infertility. It is controversial whether PCOS associate with diminished oocyte quality. The purpose of this study was to compare individual human CRC samples between PCOS patients and controls.<h4>Me ...[more]

PMID: 25432544

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