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Transcription profiling of human N-Acetyl L-cysteine induced differentiation of NHEK cells in vitro

ABSTRACT: Gene expression analysis of N-Acetyl L-cysteine induced differentiation of NHEK cells in vitro.

INSTRUMENT(S): G2565BA DNA microarray scanner [Agilent]

ORGANISM(S): Homo sapiens

SUBMITTER: Thomas Lundeberg 

PROVIDER: E-MEXP-500 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Gene expression analysis of human epidermal keratinocytes after N-acetyl L-cysteine treatment demonstrates cell cycle arrest and increased differentiation.

Edlundh-Rose Esther E   Kupershmidt Ilya I   Gustafsson Anna C AC   Parasassi Tiziana T   Serafino Annalucia A   Bracci-Laudiero Luisa L   Greco Giulia G   Krasnowska Ewa K EK   Romano Maria-Concetta MC   Lundeberg Thomas T   Nilsson Peter P   Lundeberg Joakim J  

Pathobiology : journal of immunopathology, molecular and cellular biology 20050101 4

<h4>Objectives</h4>Several cancer prevention programmes have previously been executed using treatment of antioxidant compounds. The antioxidant N-acetyl L-cysteine (NAC), a membrane-permeable aminothiol, is a sulfhydryl reductant reducing oxidised glutathione, as well as being a precursor of intracellular cysteine and glutathione. A previous report based on the cellular response to NAC treatment showed that NAC induced a 10-fold more rapid differentiation in normal primary keratinocytes as well  ...[more]

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