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Transcription profiling of mouse pre-implantation development over twelve time points from the germinal vesicle (GV) stage oocyte to the late (expanded) blastocyst

ABSTRACT: The goal of the experiments was to profile and analyze gene activity during murine pre-implantation development. Samples were collected at twelve time points from the germinal vesicle (GV) stage oocyte to the late (expanded) blastocyst.

ORGANISM(S): Mus musculus

SUBMITTER: Magdalena Zernicka-Goetz

PROVIDER: E-MEXP-51 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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A genome-wide study of gene activity reveals developmental signaling pathways in the preimplantation mouse embryo.

Wang Q Tian QT Piotrowska Karolina K Ciemerych Maria Anna MA Ciemerych Maria Anna MA Milenkovic Ljiljana L Scott Matthew P MP Davis Ronald W RW Zernicka-Goetz Magdalena M

Developmental cell 20040101 1

The preimplantation development of the mammalian embryo encompasses a series of critical events: the transition from oocyte to embryo, the first cell divisions, the establishment of cellular contacts, the first lineage differentiation-all the first subtle steps toward a future body plan. Here, we use microarrays to explore gene activity during preimplantation development. We reveal robust and dynamic patterns of stage-specific gene activity that fall into two major phases, one up to the 2-cell s ...[more]

PMID: 14723853

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