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Transcription profiling of Mycobacterium tuberculosis H37Rv and the isogenic mprA::Kmr mutant

ABSTRACT: Whole genome expression analyses between wild-type Mycobacterium tuberculosis H37Rv and the isogenic mprA::Kmr mutant. Expression analyses between these strains were conducted following growth under physiological conditions, or following exposure to non-inhibitory concentrations of SDS or Triton X-100.

INSTRUMENT(S): ScanArray 5000 [PerkinElmer]

ORGANISM(S): Mycobacterium tuberculosis

SUBMITTER: Thomas Zahrt

PROVIDER: E-MEXP-552 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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MprAB is a stress-responsive two-component system that directly regulates expression of sigma factors SigB and SigE in Mycobacterium tuberculosis.

He Hongjun H Hovey Raymond R Kane Jason J Singh Vineet V Zahrt Thomas C TC

Journal of bacteriology 20060301 6

The genetic mechanisms mediating the adaptation of Mycobacterium tuberculosis within the host are poorly understood. The best-characterized regulatory systems in this organism include sigma factors and two-component signal transduction systems. mprAB is a two-component system required by M. tuberculosis for growth in vivo during the persistent stage of infection. In this report, we demonstrate that MprAB is stress responsive and regulates the expression of numerous stress-responsive genes in M. ...[more]

PMID: 16513743

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